Vasculitis & Nephrology
Vasculitis is an autoimmune disease that can be tested for utilizing Anti-neutrophil Cytoplasmic Antibodies (ANCA). ANCA can also be helpful in diagnosing autoimmune kidney diseases such as Anti GBM disease, lupus nephritis, and ANCA associated vasculitis and glomerulonephritis.
Vasculitis & Nephrology Testing
Vasculitis
Vasculitis is an autoimmune disease that can be tested for utilizing Anti-neutrophil Cytoplasmic Antibodies (ANCA). cANCA is primarily associated with Wegener’s granulomatosis and the antigen specificity of cANCA is PR3. pANCA occurs in patients with polyarteritis nodosa, Churg-Strauss syndrome and ulcerative colitis. The antigen specificity of the pANCA in small vessel vasculitis is MPO.
Nephrology
ANCA can also be helpful in diagnosing autoimmune kidney diseases such as Anti GBM disease, lupus nephritis, and ANCA associated vasculitis and glomerulonephritis. Target autoantigens originating in neutrophil cytoplasmic granules and expressed in the cell membrane (including proteinase-3 [PR3] and myeloperoxidase [MPO]) are targeted by ANCA. These ANCA-activated neutrophils have altered flow characteristics resulting in their lodging in small vessels, particularly glomeruli, resulting in renal injury.
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Vasculitis
For an overview of Immco’s Immunogenetics testing, tap or click here.
003 ANCA (anti-neutrophil cytoplasmic antibodies) titer
Nephrology
For an overview of Immco’s Immunogenetics testing, tap or click here.
003 ANCA (anti-neutrophil cytoplasmic antibodies) titer
014 Circulating Immune Complexes (CIC)