Testes Antibody Titer

Category: Endocrinology and Infertility
Test Code: 491
Disease: Infertility
Methodology: Indirect Immunofluorescence
Substrate: Primate Testes
Reference Range: Negative: <1:10
Units: Titer
CPT Code: 86255
Schedule / Turnaround Time: Assay performed once weekly. Report availability is within one week from the time of specimen receipt.
Specimen Requirements:

Specimen need not be refrigerated or frozen. Collect 2-3 ml of blood in a red top or serum separator tube. If possible, separate serum from clot and place into white tube provided with Immco Diagnostics’ collection kits. If separation facilities are not available, the blood can be sent in the tube used for collection.

Sample Stability:

Sample is stable at ambient temperature during shipment. If sample is stored prior to shipment, it is stable refrigerated (2-8˚C) up to five days and frozen (-20˚C or lower) up to one year.

Relevance:

Antibodies to steroid cell antigens have been identified in association with premature menopause, infertility and in patients with in vitro fertilization (IVF). The appearance of these antibodies often precedes onset of ovarian failure. Patients with these disorders may have autoantibodies to testicular Leydig cells, ovarian granulosa cells and placental syncytiotrophoblasts.Clinical Relevance: Antibodies to steroid cell antigens have been identified in association with premature menopause, infertility and in patients with in vitro fertilization (IVF). The appearance of these antibodies often precedes onset of ovarian failure. Patients with these disorders may have autoantibodies to testicular Leydig cells, ovarian granulosa cells and placental syncytiotrophoblasts.