HLA DQ 8 (Diabetes)
|Methodology:||Polymerase chain reaction (PCR) with Sequence Specific Primers|
|Reference Range:||Reported positive or negative.|
|CPT Code:||83891; 83898(x31); 83894; 83912.|
|Schedule / Turnaround Time:||Assay performed daily. Report availability is within 48 hours from the time of specimen receipt.|
Specimen must be kept in ambient temperature and should not be refrigerated or frozen. Collect 5 ml of blood in a lavender top Hemogard (EDTA) tube.
Sample is stable at ambient temperature and should be analyzed within 76 hours.
In Europe, DQ8 is associated with juvenile diabetes and celiac disease. The highest risk factor for Type 1 diabetes is the HLA DQ8/DQ2 phenotype. In parts of eastern Scandinavia both DQ2 and DQ8 are high increases frequencies of late onset Type I and ambiguous Type I/II diabetes. In the United States, however there appears to be shift in autoimmune disease risk for immigrants from Mexico. Increased immunoreactivity of Hispanics in Houston appear to be associated with DR4-DQ8. The haplotype may incur the highest risk for rheumatoid arthritis. Many disease associated with DQ8 have dual linkage with DR4, and certain DR4 (*04:05) have independent and dependent risk association with DQ8, for example with juvenile diabetes.