| Test Number | 270 |
| Method | IFA |
| Reference Range |
Negative: <1:10
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| CPT Code | 86255 x 2 |
| Schedule Turnaround Time | Assay performed once weekly. Report availability is within one week from the time of specimen receipt. |
| Specimen Requirements | Specimen need not be refrigerated or frozen. Collect 5-10 ml of blood in a red top or serum separator tube. If possible, separate serum from clot and place into orange tube provided with IMMCO collection kits. Do not puncture top of orange tube. If separation facilities are not available, the blood can be sent in the tube used for collection |
| Sample Stability | Sample is stable at ambient temperature during shipment. If sample is stored prior to shipment, it is stable refrigerated (2-8˚C) up to five days and frozen (-20˚C or lower) up to one year. |
| Clinical Relevance | Antibodies to GBM occur in glomerulonephritis and Goodpasture Syndrome. Rapidly progressive glomerulonephritis (RPGN) is characterized by crescentic glomerulonephritis. RPGN may be classified into 3 types: 1) Immune complex mediated disease characterized by the presence of anti-DNA antibodies or anti-streptococcal antibodies; 2) Glomerular basement membrane (GBM) mediated glomerulonephritis and Goodpasture syndrome; 3) Anti-neutrophil cytoplasmic antibody (ANCA) associated glomerulonephritis.
The immunoglobulins are almost exclusively of the IgG subtype. However rare reports of non-IgG class anti-GBM antibodies, especially IgA GBM have been reported. In these patients IgA can be found on its own or may be found together with IgG in approximately 10% to 20% of cases.
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| Antibodies |
- Anti-Glomerular Basement Membrane (GBM) Antibodies
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| Autoimmune Diseases |
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